• Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence 

      Lekva, Tove; Roland, M.C.P.; Estensen, M.E.; Norwitz, Errol R.; Tilburgs, T.; Henriksen, Tore; Bollerslev, Jens; Normann, K.R.; Magnus, P.; Olstad, Ole Kristoffer; Aukrust, Pål; Ueland, T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Senescence in placenta/fetal membranes is a normal phenomenon linked to term parturition. However, excessive senescence which may be induced by telomere attrition, has been associated with preeclampsia (PE). We hypothesized that the telomerase complex in peripheral blood mononuclear cells (PBMC) and circulating telomere associated senescence markers would be dysregulated in women with PE. We measured ...